Changes in the Retina and Choroid of the Eye with Painful Neovascular Glaucoma of Post-Thrombotic and Diabetic Genesis

Purpose. To determine the similarities and diff erences in morphological changes in the choroid and
retina of the eye with terminal pain neovascular glaucoma of post-thrombotic and diabetic genesis.
Materials and methods. 57 enucleated eyeballs (344 preparations) were studied: group 1 – 156
preparations of 26 enucleated eyeballs with NVG developed due to thrombosis of the central retinal
vein (CRV) or its branches in patients with arterial hypertension; group 2 – 188 drugs from 31 eyes
with NVG developed in patients with diabetes mellitus (DM) with proliferative diabetic retinopathy
(PDR). Histological sections were stained with hematoxylin and eosin, and according to Van Gieson.
5–6 sections of each eyeball were analyzed using an Olimpus BX-41 microscope with a magnifi cation
of x 200–400.
Results and discussion. Morphologically revealed generalized microthrombosis in the tissues of
enucleated eyes with NVG of postocclusal origin, in contrast to eyes with NVG on the background
of DM. Revealed signifi cantly expanded perivasal gaps in the ciliary body (CB), iris, choroid and
retina, signifi cantly expanded canal-like formations between the muscle fi bers of CB and iris, cystlike
formations in retina can be regarded as a result of congestion of the prelimphatic pathways of
the outfl ow of tissue fl uid from the structures of the eye. In the group with post-thrombotic NVG,
in contrast to the group with diabetic NVG, blood clots in the vessels of the CB were 4.1 times more
common, blood clots in the vessels of the iris were 4 times more common, 4 8 times more often – in
the vessels of the choroid. In the group with NVG on the background of DM, in contrast to the group
with post-thrombotic NVG hemorrhages in the processes of the CB were 5.3 more often, 23 times
more often a neoplasm of the vessels of the vitreous body was detected and fi brous vitreoretinal
moorings were determined 26.3 times more often.
Conclusions. The combination of morphological manifestations suggests that in patients with
diabetic genesis of terminal NVG, in comparison with post-thrombotic NVG, the infl ammatory
reaction is more pronounced, bleeding of the vascular wall and more pronounced tendency to
hyperproliferation of blood vessels and connective tissue. The data obtained justify the expected
complications in the area of potential surgical intervention and pathogenetically directed
pharmacotherapeutic eff ects to optimize the complex treatment of NVG of various origins.